Table 3 Standardized incidence ratios of the most overrepresented non-component cancers

From: Extended spectrum of cancers in PTEN hamartoma tumor syndrome

Cancer

Expected

Observed

SIRa

CI

P value

All PHTS with tier 1 and tier 2 PTEN variants (n = 701)

Ovarian

0.88

10

11.37

5.77–20.26

<0.001

Prostate

1.94

8

4.12

1.92–7.83

0.001

Soft tissue

0.47

5

10.70

3.92–23.73

<0.001

Lung

2.77

5

1.80

0.66–4.00

0.210

PHTS with tier 1 PTEN variants (n = 514)

Ovarian

0.43

1

2.34

0.12–11.47

0.419

Prostate

1.27

7

5.52

2.41–10.92

<0.001

Soft tissue

0.29

3

10.37

2.64–28.23

0.003

Lung

1.29

4

3.11

0.99–7.54

0.051

  1. SIR standardized incidence ratio, CI confidence interval.
  2. aSIR relative to cases from the Surveillance, Epidemiology, and End Results database (SEER).
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