Fig. 2: Clinical and Radiographic Assessment of Tumor Response.

a Clinical image of the baseline superficial CDS lesion on the right anterior thigh, measuring approximately 2 cm in diameter with focal ulceration. b Clinical image of the CDS tumor at Cycle 1, Day 21 of treatment, showing surrounding erythema and persistent ulceration. c Baseline PET scan of the right thigh and pelvis, showing multiple hypermetabolic soft tissue masses in the anterior right thigh subcutaneous fat, the largest measuring 2.8 × 2.1 cm. FDG-avid disease is also present in the right femur. Frontal (left) and lateral (right) views. d PET scan at 4 months of treatment demonstrating a reduction in FDG-avid masses in both the right thigh and right femur. Frontal (left) and lateral (right) views.