Fig. 1: The association between IL-11 signaling and various types of tumors. | npj Precision Oncology

Fig. 1: The association between IL-11 signaling and various types of tumors.

From: IL-11/IL-11R signal inhibition by 9MW3811 remodels immune tumor microenvironment and enhances anti-tumor efficacy of PD-1 blockade

Fig. 1

A IL-11 is more overexpressed in CHOL, ESCA, HNSC, LUSC, LUAD, COAD, CESC, and BRCA (data from The Cancer Genome Atlas (TCGA) than normal tissues (data from the Genotype-Tissue Expression (GTEx). B Kaplan–Meier survival analysis of IL-11 mRNA levels for BRCA, CESC, CHOL, ACC, LUAD, PAAD, UCS, and COAD with datasets from TCGA and GTEx. C Relative contributions of IL-11 in different cancer types. The scores were evaluated by AIBERT®. D The impact of genetic loss of IL-11Rα on tumor growth was evaluated using MC38 cell line-derived tumor models with IL-11Rα knockout (IL-11RαKO-MC38). MC38 or IL-11RαKO-MC38 cells were inoculated subcutaneously into separate groups of C57BL/6J mice. Data are presented as mean ± SEM, n = 8. E The effects of genetic loss of IL-11Rα on tumor growth were assessed in Hepa1-6 tumor models using C57BL/6J wild-type mice and IL-11Rα knockout mice (IL-11RαKO-mice). Hepa1-6 cells were inoculated subcutaneously into separate groups of C57BL/6 J wild-type or IL-11Rα KO mice, Data are presented as mean ± SEM, n = 6.

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