Fig. 3: Distinct macrophage subpopulations in the cervical cancer microenvironment with focus on SPP1+ macrophages. | npj Precision Oncology

Fig. 3: Distinct macrophage subpopulations in the cervical cancer microenvironment with focus on SPP1+ macrophages.

From: Deciphering the cellular and molecular landscape of cervical cancer progression through single-cell and spatial transcriptomics

Fig. 3

A UMAP plot showing the clustering of macrophage subtypes identified in cervical cancer samples. B Dot plot illustrating the expression of marker genes for each macrophage subtype. C Bar plot displaying the distribution of macrophage subtypes across different conditions. D Heatmap showing the distribution preference across macrophage subtypes. E GO enrichment analysis for each macrophage subtype. F Violin plots displaying the expression levels of key genes involved in the ERK1/ERK2 pathway across macrophage subtypes. G UMAP plot focusing on SPP1+ macrophages. H, I Pseudotime trajectory analysis of SPP1+ macrophages across different conditions. J The inflammatory response pathway scored in SPP1+ macrophages along the pseudotime trajectory.

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