Fig. 8: A schematic illustration of the molecular mechanism of LHX1-DT in inhibiting the development of RCC. | npj Precision Oncology

Fig. 8: A schematic illustration of the molecular mechanism of LHX1-DT in inhibiting the development of RCC.

From: m6A reader IGF2BP2-stabilized lncRNA LHX1-DT inhibits renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-590-5p

Fig. 8

The expression of MELLT14, a key regulatory factor of m6A, is downregulated, and the level of m6A is also downregulated. The m6A reader protein IGF2BP2, mediated by METTL14, recognized the m6A modification site on LHX1-DT and promoted its stability and expression. Additionally, LHX1-DT acted as a ceRNA by sponging miR-590-5p, which in turn downregulated PDCD4, thereby inhibiting RCC cell proliferation and metastasis.

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