Fig. 1: Detection of CH in metastatic urologic cancers.

a Study design. b Bar chart showing CH prevalence in mUC and mRCC at different detection thresholds. Patient numbers are indicated above bars. c Comparison of matched white blood cell (WBC) DNA and cell-free DNA (cfDNA) variant allele frequencies (VAFs). Inset plot shows VAF < 2%. d [Left] Bar chart showing the percentage of CH+ patients with mutations in the 15 most commonly mutated genes. Differences in per gene frequency between cancer types is indicated with unadjusted and Benjamini-Hochberg corrected p-values (denoted by asterisks). Patient numbers are provided to the left of each bar. [Right] Dot plot showing the WBC DNA VAFs for each gene in log10 scale. e Bar chart showing the distribution of the number of CH mutations detected in each patient (patient numbers are provided at the top of the chart). The superimposed dotplot shows the WBC DNA VAFs in log10 scale. f Box plot comparing the age at baseline blood draw for patients with CH detected at different WBC VAF thresholds. g Dot plot showing the CH prevalence across different age groups. The human figure in Fig. 1a was obtained and modified from Wikimedia Commons (author: Cancer Research UK) available under the Creative Commons Attribution-Share Alike 4.0 International license: https://commons.wikimedia.org/wiki/File:Diagram_showing_where_in_the_body_cancer_tends_to_spread_to_CRUK_381.svg.