Fig. 2: Intersection of CH- and ctDNA-derived somatic mutations in the blood.

a Bar chart [top] showing the percentage of all somatic mutations detected in cfDNA that are CH-derived, on a per gene basis. Bar chart [bottom] indicates the total number mutations detected in each gene across all patients. Genes with notable relevance in solid tumors are indicated in bold typeface. b Oncoprint showing the breakdown of somatic mutations among patients with CH and/or ctDNA mutations. For each gene, the upper tracks in lighter gray background indicate CH mutations and the darker gray track indicates ctDNA mutations. The top three bar charts indicate the highest per patient variant allele frequency (VAF) for a ctDNA mutation, the highest VAF for a CH mutation, and the total mutation count per patient, respectively. The bar chart to the right of the oncoprint shows the number of mutations detected per gene with the mutation VAFs shown in the superimposed dot plot.