Fig. 2: BRAF amplification was assessed using FFPE interphase FISH.
From: RAS pathway targeted therapy in patients with DICER1-associated sarcomas
Red signals represent the BRAF gene (7q34), and green signals correspond to the chromosome 7 centromere probe (D7Z1). A, B No BRAF amplification (copy-neutral status) is observed in interphase FISH of the initial diagnosis specimen (A) or a specimen collected 14 months later (B). C Interphase FISH demonstrates BRAF amplification, with more than ten red signals corresponding to the BRAF gene (7q34) per cell, alongside two green signals indicating two copies of the chromosome 7 centromere.
