Fig. 3: Immune cell infiltrate and immune gene expression in EOEGC, IOEGC, and AOEGC.
From: Multi-omic characterization of early-onset esophagogastric cancer
A Computationally inferred intratumoral immune population. The heatmap indicates fold change of IOEGC relative to EOEGC in median immune fraction according to quanTIseq. B The heatmap indicates fold change of AOEGC relative to EOEGC in median immune fraction according to quanTIseq. Tumor microenvironment cell fractions were analyzed among cohorts using nonparametric Kruskal-Wallis testing. The Benjamini-Hochberg method was utilized to adjust p-values for multiple comparisons (*q < 0.05; **q < 0.01; ***q < 0.001). C For cell types with median values of “0”(Ex: monocytes and CD4+ T cells), the percentage of tumors with nonzero immune infiltrates were compared. D Fold change gene expression levels in transcripts per million (TPM) of immune checkpoint genes IOEGC relative to EOEGC. E Fold change gene expression levels in TPM of immune checkpoint genes AOEGC relative to EOEGC. Mann-Whitney U test used to determine statistically significant differences in immune gene expression. The Benjamini-Hochberg method was utilized to adjust p-values for multiple comparisons (*q < 0.05; **q < 0.01; ***q < 0.001).
