Table 1 Patient Clinicopathologic Characteristics

From: Multi-omic characterization of early-onset esophagogastric cancer

   

EOEGC

IOEGC

AOEGC

Count (N)

530

1744

2901

Median Age [range]

43 [14–49]

59 [50–64]

73 [65–>89]

Sex

Male

66.0% (350/530)

74.9% (1306/1744)

73.7% (2139/2901)

Female

34.0% (180/530)

25.1% (438/1744)

26.3% (762/2901)

Lineage

Esophagogastric Junction Carcinoma

39.4% (209/530)

50.8% (886/1744)

50.7% (1470/2901)

Gastric Adenocarcinoma

53.4% (283/530)

34.8% (607/1744)

33.6% (974/2901)

Esophageal Carcinoma

7.2% (38/530)

14.4% (251/1744)

15.7% (457/2901)

Histology

Adenocarcinoma

76.4% (405/530)

74.8% (1304/1744)

75.8% (2198/2901)

Squamous

4.5% (24/530)

10.8% (188/1744)

12.4% (359/2901)

Other/mixed

19.1% (101/530)

14.4% (252/1744)

11.8% (344/2901)

Lauren subtype

Diffuse

12.8% (68/530)

6.1% (107/1744)

5.3% (153/2901)

Intestinal

0.6% (3/530)

0.9% (16/1744)

1.4% (42/2901)

Mixed/unclear

86.6% (459/530)

93% (1621/1744)

93.3% (2706/2901)

Specimen site

Primary

60.6% (321/530)

65.5% (1162/1744)

75.7% (2197/2901)

Metastatic

Liver

4.3% (23/530)

4.2% (74/1744)

3.3% (96/2901)

Peritoneum/Retroperitoneum

7.5% (40/530)

7.4% (129/1744)

6.7% (195/2901)

Lymph Node

5.3% (28/530)

4.8% (84/1744)

3.4% (99/2901)

Other

22.3% (118/530)

16.9% (295/1744)

10.8% (314/2901)

Smoking History

Yes

94.6% (52/55)

94.4% (303/321)

95.5% (429/449)

No

5.5% (3/55)

5.6% (18/321)

4.5% (20/449)

Race

White

64.2% (174/271)

69.5% (763/1098)

78.8% (2009/2551)

Black

19.2% (52/271)

16.6% (182/1098)

11.3% (289/2551)

Asian/Pacific Islander

8.1% (22/271)

6.6% (73/1098)

5.2% (132/2551)

Other

8.5% (23/271)

7.3% (80/1098)

4.7% (121/2551)

Ethnicity

Not Hispanic or Latino

72.5% (195/269)

82.3% (919/1116)

87.9% (2231/2537)

Hispanic or Latino

27.5% (74/269)

17.7% (197/1116)

12.1% (306/2537)

  1. EOEGC: Age < 50; IOEGC: 50 ≤ Age < 65; AOEGC: Age ≥ 65.
  2. TCGA cohort (Lauren subtype): Diffuse subtype includes signet ring cell carcinoma; Intestinal subtype includes tubular stomach adenocarcinoma, papillary stomach adenocarcinoma, and mucinous stomach adenocarcinoma.
  3. Primary tumor sites were defined as esophagus, gastroesophageal junction, stomach, or gastric. Metastatic tumor sites included liver, peritoneum/retroperitoneum, lymph node, or other (sites not classified as primary or one of the specified metastatic sites).
  4. Race and ethnicity data is self-reported.