Table 1 Key enzymes involved in GD2 biosynthesis, showing their substrates and products in the ganglioside synthesis pathway
Enzyme | Abbreviation | Catalyzed substrate | Reaction Product |
|---|---|---|---|
Beta-1,4-galactosyltransferase 6 | B4GALT6 | Glucosylceramide (Glu-Cer) | Lactosyl ceramide (Lac-Cer) |
ST3 Beta-Galactoside Alpha-2,3-Sialyltransferase 5 | ST3GAL5 | Lac-Cer | GM3 |
ST8 Alpha-N-Acetyl-Neuraminide Alpha-2,8-Sialyltransferase 1 | ST8SIA1 | GM3 | GD3 |
Beta-1,4-N-Acetyl-Galactosaminyltransferase 1 | B4GALNT1 | GM3 or GD3 | GM2 or GD2 |
Beta-1,3-Galactosyltransferase 4 | B3GALT4 | GM2/GD2 precursors | GD1b |
Sterol O-Acyltransferase | SOAT | GD2 | O-Ac-GD2 |
