Fig. 2: Mutation landscape of ECM1 and ECM2 subtypes.

Mutation profiles of key genes in the ECM1 and ECM2 subtypes. On the left, ECM1 shows a higher frequency of mutations in IDH1 (94%), TP53 (64%), ATRX (52%), and CDKN2A (8%) compared to ECM2. The ECM2 subtype has a relatively lower mutation frequency, with IDH1 (94%) being the most frequent mutation, followed by TP53 (46%) and ATRX (42%). Mutation types are color-coded as follows: inframe mutations (putative driver) in red, missense mutations (putative driver) in green, inframe mutations (unknown significance) in light brown, missense mutations (unknown significance) in blue, splice mutations (putative driver) in orange, truncating mutations (putative driver) in purple, amplifications in dark green, and deep deletions in dark blue, red-labeled genes represent driver mutation, black-labeled genes represent passenger mutation. The bars next to each mutation denote the frequency of each mutation in the respective subtype.