Table 1 Summary of patient information
ID | Age at diagnosis (years) | Diagnosis methods of ovarian cancer | FIGO stage | BRCA mutation detected by WES | Treatment before sample collection | Age at sample collection (years) | Timing of sample collection | Sample | Histology | Treatment before olaparib treatment | Response to prior platinum regimen | Duration of olaparib maintenance therapy (months) | Treatment after olaparib | Outcome |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
S1 | 56 | PDS | IIIC | Negative | None | 56 | PDS | Ovary | HGSOC | TC ×8 | PR | 7 | TC ×4 → Niraparib 9 months → TC ×2 → PLD ×8 → NGT ×1 | AWD |
S2 | 63 | Ascites cytology | IVB | Not analyzed (low quality) | TC ×8 → TC ×10 → PLD ×10 → NGT + Bev ×5 → NGT ×3 → CDGP ×3 → CPT-11 ×1 | 68 | Surgery for recurrence | Fallopian tube | HGSOC | CPT-11 ×3 → TC ×6 | CR | 27 | TC ×2 | DOD |
S3 | 48 | Ascites cytology | IVA | Germline | TC ×5 +Bev ×3 | 49 | IDS | Ovary | HGSOC | TC ×4 +Bev ×3 → Bev maintenance ×10 → TC + Bev ×9 | CR | 54 | Ongoing | NED |
S4 | 49 | Exploratory laparotomy (BSO) | IIIB | Negative | TC ×6 → CmP/P ×3 → TC ×2 → PLD ×4 → TC ×3 → CDGP ×5 → DTX ×3 → NGT ×7 → CPT-11 ×4 | 56 | Surgery for recurrence | Vaginal stump | HGSOC | CDGP ×6 | PR | 38 | Onset of MDS followed by treatment for MDS | DOD |
R1 | 38 | PDS | IIIC | Negative | None | 38 | PDS | Ovary | HGSOC | TC ×6 → wPTX ×5 → PLD ×3 → PLD ×6 → CPT-11 ×2 → NGT ×2 → GEM ×3 → CDGP + wPTX ×10 → CBDCA ×3 | PR | 2 | CBDCA ×1 | DOD |
R2 | 52 | Biopsy of abdominal wall metastasis | IVB | Negative | TC + Bev ×6 → TC ×7 | 53 | IDS | Ovary | HGSOC | DC ×4 +Bev ×3 → Bev maintenance ×11 → Surgery → DC ×3 | PR | 4 | PLD + Bev ×3 → NGT + Bev ×3 → GEM ×3 | DOD |
R3 | 77 | Exploratory laparotomy (resection of peritoneal metastases) | IIIC | Negative | None | 77 | PDS | Peritoneum | HGSOC | TC ×8 → TC ×4 → TC ×8 → PLD ×5 → GEM ×3 → DTX ×4 → wPTX ×8 → CPT-11 ×3 → TC ×2 → GEM ×4 → CDGP ×3 | PR | 2 | wPTX ×3 → GEM ×3 → CDGP ×8 | DOD |
R4 | 60 | Ascites cytology | IIIC | Negative | TC ×6 | 60 | IDS | Omentum | HGSOC | TC ×3 | PR | 3 | PLD ×2 → NGT ×2 | DOD |
