Fig. 2: Morphological progression of PDTs captured using brightfield microscopy.

Brightfield microscopy images illustrating the morphological evolution of PDTs derived from pediatric low-grade gliomas, a meningioma, an ependymoma, pediatric high-grade gliomas, a CNS tumor with BCOR alteration, medulloblastomas, and an atypical teratoid/rhabdoid tumor (ATRT). Scale bar: 100 μm. Images were acquired using a 20 ×/ 0.4 objective with a digital imaging system (ZOE, Bio-Rad). PDT Patient-derived tumoroids.