Table 2 Univariate and multivariate Cox regression analysis for CRC-specific survival

From: Siglec-14-LGALS3BP glycoimmune axis shapes tumor-associated macrophage polarization and confers poor outcome in colorectal cancer

CRC-specific survival

 

Univariate

  

Multivariate

 

Variable

HR

95% CI

P value

HR

95% CI

p value

Age (≧65 vs <65)

3.317

1.374–8.003

0.008

4.330

1.454–12.899

0.008

Gender (male vs female)

0.884

0.397–1.968

0.763

1.680

0.615–4.587

0.311

Stage (late vs early)

1.447

0.648–3.231

0.368

0.991

0.323–3.045

0.988

Differentiation (Poorly vs others)

4.485

1.859–10.823

0.001

5.704

1.737–18.733

0.004

Location (left vs right)

0.831

0.372–1.857

0.651

1.682

0.610–4.637

0.315

CEA (>5 vs ≦5)

4.364

1.808–10.534

0.001

2.764

0.866–8.824

0.086

CA19-9 (>37 vs ≦37)

4.626

2.022–10.585

<0.001

4.109

1.248–13.534

0.020

MSI (MSS vs MSI)

0.630

0.184–2.153

0.461

0.276

0.063–1.200

0.086

Round cell infiltration (positive vs negative)

1.019

0.446–2.330

0.964

1.043

0.379–2.867

0.935

Lymphatic invasion (positive vs negative)

3.402

1.523–7.599

0.003

1.328

0.452–3.904

0.606

SIGLEC14 (positive vs negative)

0.707

0.317–1.577

0.397

1.005

0.389–2.596

0.992

LGALS3BP (high vs low)

2.484

1.085–5.685

0.031

5.948

1.899–18.630

0.002

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