Table 3 Significant correlations between the clinical/demographic variables and the rare cells identified by HDSCA in the PB samples collected from patients with precursor states and overt MM

From: Characterizing circulating rare cells in peripheral blood for detecting and monitoring multiple myeloma and precursor states

HDSCA analyte

Clinical variable

Method

Correlation value

P-value

D | 138 | BCMA-Memb

Monosomy 13/ loss RB1/ Del 13

Wilcoxon

−4.1405

0.0000

D | 138 | BCMA-Memb

PC percentage in left core

Spearman

0.5085

0.0001

D | 138 | BCMA-Memb

FLOW aberrant PCs from total analyzed percent

Spearman

0.4317

0.0003

D | 138

serum free light chain ratio

Spearman

0.4173

0.0004

D | 138 | BCMA-Memb

PC percentage in left aspirate

Spearman

0.4602

0.0007

D | 138

Bence Jones

Spearman

0.4398

0.0009

D | 138 | BCMA-Memb

Bence Jones

Spearman

0.4237

0.0014

D | 138 | BCMA-Memb

serum free light chain ratio

Spearman

0.3636

0.0025

D | 138 | BCMA-Memb

PC percentage in right core

Spearman

0.3996

0.0025

D | 138 | BCMA-Memb

PC percentage in right aspirate

Spearman

0.3729

0.0046

Total 138+ Cells

Del of CDKN2C (1q32)

Wilcoxon

−2.7221

0.0065

Total BCMA-Memb Cells

Del of CDKN2C (1q32)

Wilcoxon

−2.6075

0.0091

Total BCMA+ Cells

Age

Spearman

−0.3124

0.0101

D | 138

CD27 simplified

Wilcoxon

2.5666

0.0103

Total 138+ Cells

Monosomy 13/ loss RB1/ Del 13

Wilcoxon

−2.5580

0.0105

D | 138

Monosomy 13/ loss RB1/ Del 13

Wilcoxon

−2.5218

0.0117

Total Events

Del of CDKN2C (1q32)

Wilcoxon

−2.4928

0.0127

D | 138 | BCMA-Memb

Gain CKS1B (1q21)-trisomy 1

Wilcoxon

−2.4855

0.0129

D | 138 | BCMA-Memb

IgM

Spearman

−0.2966

0.0148

Total BCMA-Memb Cells

Monosomy 13/ loss RB1/ Del 13

Wilcoxon

−2.4279

0.0152

D | 138

Alive

Wilcoxon

2.4267

0.0152

D | 138 | BCMA-Memb

IgA

Spearman

−0.2914

0.0167

D | BCMA-Peri|45

Gain FGFR3 /trisomy 4

Wilcoxon

−2.3905

0.0168

Total BCMA-Peri Cells

Gain FGFR3 /trisomy 4

Wilcoxon

−2.3905

0.0168

Total Events

Age

Spearman

−0.2863

0.0188

Total BCMA+ Cells

Del of CDKN2C (1q32)

Wilcoxon

−2.3209

0.0203

D | BCMA-Peri

Gain FGFR3 /trisomy 4

Wilcoxon

−2.3108

0.0208

D | BCMA-Memb|45

Gain FGFR3 /trisomy 4

Wilcoxon

−2.3108

0.0208

D | 138

IgM

Spearman

−0.2818

0.0209

D | 138

urine immunofixation light chain

Wilcoxon

2.2402

0.0251

D | BCMA-Memb

Gain 17p/TP53 - trisomy 17

Wilcoxon

−2.2381

0.0252

D | 138 | BCMA-Peri|45

Gain FGFR3 /trisomy 4

Wilcoxon

−2.2311

0.0257

Total BCMA-Memb Cells

Bence Jones

Spearman

0.3021

0.0264

D | 138

PC percentage in left core

Spearman

0.3094

0.0271

Total Events

Bence Jones

Spearman

0.2980

0.0286

Total BCMA+ Cells

Bence Jones

Spearman

0.2971

0.0291

D | 138 | BCMA-Memb|45

Alive

Wilcoxon

−2.1753

0.0296

Total 138+ Cells

Bence Jones

Spearman

0.2960

0.0298

Total BCMA-Memb Cells

Age

Spearman

−0.2654

0.0300

D | 138 | BCMA-Memb|45

Age

Spearman

−0.2619

0.0322

Total BCMA-Peri Cells

Age

Spearman

−0.2607

0.0331

D | 138

CD45

Wilcoxon

−2.1301

0.0332

D | 138 | 45

Alive

Wilcoxon

−2.1270

0.0334

D | 138

CD19 simplified

Wilcoxon

2.1190

0.0341

D | 138

IgA

Spearman

−0.2592

0.0342

Total Events

Gain FGFR3 /trisomy 4

Wilcoxon

−2.1116

0.0347

Total BCMA+ Cells

Gain FGFR3 /trisomy 4

Wilcoxon

−2.1116

0.0347

D | BCMA-Memb

Gain FGFR3 /trisomy 4

Wilcoxon

−2.0917

0.0365

D | 138 | BCMA-Memb

gain CCND1/MYEOV/IGH -trisomy 11

Wilcoxon

−2.0781

0.0377

D | 138 | BCMA-Peri|45

serum free light chain ratio

Spearman

−0.2538

0.0382

D

serum free light chain ratio

Spearman

−0.2527

0.0391

D | 138 | BCMA-Memb

Del of CDKN2C (1q32)

Wilcoxon

−2.0487

0.0405

Total BCMA-Peri Cells

serum immunofixation

Wilcoxon

2.0421

0.0411

D | 138 | 45

gain CCND1/MYEOV/IGH -trisomy 11

Wilcoxon

−2.0393

0.0414

D | 138

cyKAPPA

Wilcoxon

2.0305

0.0423

D | BCMA-Memb|45

Del of CDKN2C (1q32)

Wilcoxon

−1.9914

0.0464

Total 138+ Cells

PC percentage in left core

Spearman

0.2800

0.0466

Total 138+ Cells

Gain CKS1B (1q21)-trisomy 1

Wilcoxon

−1.9787

0.0478

D | BCMA-Peri|45

serum immunofixation

Wilcoxon

1.9762

0.0481

D | BCMA-Peri|45

Age

Spearman

−0.2416

0.0489

  1. D DAPI, 138: CD138, 45: CD45, Peri perinuclear localization of BCMA, Memb membrane bound BCMA, FLOW flow cytometry. Two-sided Wilcoxon rank sum test or Spearman correlation analyses with significance determined at a P-value < 0.05.
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