Fig. 2: Methodology of manuscript compilation with the development of 5 overarching dimensions and 10 distinct practice-oriented principles.

Structured development of a position paper on the responsible use of LLMs in precision oncology based on expert discussions and iterative consensus-building. An interdisciplinary German team of experts drafted five dimensions, each representing a thematic complex of responsible LLM-use for precision oncology with real-world data. From these more abstract complexes, ten practice-oriented, actionable principles were developed deductively through group discussions and repeated manuscript reviews. The manuscript underwent two working processes: initial drafting, team-based revisions, and consensus formation, followed by validation through discussions with local center experts within Cancer Core Europe (CCE). Final approval was granted by the CCE Board to ensure alignment with institutional and scientific standards.