Fig. 2: Genomic landscape of aSCC tumors in the tissue biopsy cohort. | npj Precision Oncology

Fig. 2: Genomic landscape of aSCC tumors in the tissue biopsy cohort.

From: Comprehensive molecular landscape of anal squamous cell carcinoma: analysis of tissue and liquid biopsies from 1844 patients

Fig. 2

A Oncoplot showing the distribution of the 12 most frequently altered genes in aSCC within the tissue biopsy cohort. Genes and their corresponding frequencies are listed on the left. HPV subtype (HPV), tumor mutational burden (TMB), and microsatellite instability status (MSI) are overlaid for each patient. Each sample is color-coded based on the type of gene alteration detected. B Pie chart illustrating the distribution of the 705 PIK3CA alterations identified in the tissue biopsy cohort. C Prevalence of chromosomal copy number losses (light blue) and gains (yellow) in aSCC within the tissue biopsy cohort. Key genes are indicated for select chromosome arms. D Heatmap showing the correlation between HPV status and molecular alterations in the tissue biopsy cohort. Intense red indicates a correlation observed in more than 50% of the samples, while dark blue represents a correlation close to 0%.

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