Fig. 5: Genomic landscape of aSCC tumors in the liquid biopsy cohort.

A Butterfly chart depicting the prevalence of the 11 most frequently altered genes in the tissue biopsy cohort (orange) and the liquid biopsy cohort (dark blue). B Pie chart showing the proportion of the different ESCAT types among the 263 alterations identified. C Bar plot showing the prevalence of the 25 most common alterations classified according to the ESCAT classification. D Heatmap showing the correlation between HPV status and molecular alterations in the liquid biopsy cohort. Intense red indicates a correlation observed in more than 50% of the samples, while dark blue represents a correlation close to 0%. E Heatmap illustrating the concordance of the 12 most frequently altered genes in the 29 patients with both tissue and liquid biopsy samples. Orange squares indicate alterations found in both liquid and tissue biopsies, light blue squares represent alterations identified only in the liquid biopsy, and dark blue squares represent alterations exclusive to the tissue biopsy.