Fig. 2: The change in CSF ctDNA maxVAF from baseline (T0) to T3, along with the clinical response and survival status. | npj Precision Oncology

Fig. 2: The change in CSF ctDNA maxVAF from baseline (T0) to T3, along with the clinical response and survival status.

From: Serial monitoring of cerebrospinal fluid in patients with leptomeningeal metastases in lung cancer via the Ommaya reservoir as a predictive indicator of therapeutic efficacy and clinical prognosis

Fig. 2

The swimmer plot displays the changes in CSF ctDNA maxVAF from baseline to the last detection time point, as well as the corresponding treatment status (RE/Non-RE) of patients who received at least one treatment (n = 86), during the intervals. Each bar length represents the duration from baseline to the last follow-up. The line segments are color-coded according to the results of the RANO assessment, up to the study endpoint. The triangles in the plot indicate whether CSF ctDNA was increased or decreased compared to baseline. Abbreviation: CSF cerebrospinal fluid, ctDNA circulating tumor DNA, maxVAF max variant allele frequency, RANO response assessment in neuro-oncology.

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