Fig. 6: Core regulatory circuitry (CRC) and dependencies in Ewing sarcoma compared to other pediatric cancers and normal tissues. | npj Precision Oncology

Fig. 6: Core regulatory circuitry (CRC) and dependencies in Ewing sarcoma compared to other pediatric cancers and normal tissues.

From: The hegemonic EWSR1::ETS oncoprotein overrules core regulatory circuitry principles in Ewing sarcoma

Fig. 6: Core regulatory circuitry (CRC) and dependencies in Ewing sarcoma compared to other pediatric cancers and normal tissues.

A–C Bar plots of the top 20 genes with dependencies enriched in Ewing sarcoma (A), NB (B), and RMS (C), using the CRISPR (DepMap 23Q4 public + score, chronos) dataset. The y-axis represents the log10 of the adjusted p value from DepMap (dependency in the lineage compared to all other models). CRC genes are shown in brown, TFs in orange, and other genes in gray. D Heatmap of TFs involved in different differentiation processes, with only those TFs that have motifs in JASPAR reported. Each column represents a sample, and each row represents a gene. Black boxes indicate TFs that are members of the CRC in the sample. E Alternative CRC regulation in Ewing sarcoma.

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