Fig. 2: TSP subtype switch between sequencing methods. | npj Precision Oncology

Fig. 2: TSP subtype switch between sequencing methods.

From: Cross-platform comparison of gene expression-based cancer molecular subtyping reveals discrepancies with exome capture methods

Fig. 2

A Sankey diagrams demonstrating whether each TSP is basal-like (gene A > gene B) or classical (gene A < gene B) in whole transcriptome (left bars) and exome capture (right bars). B Heatmap of gene expression by whole transcriptome (left) and exome capture (right) of the genes used in PurIST. Each column represents a sample, and columns are ordered by increasing basal-like probability from whole transcriptome RNA-seq. Genes (rows) are ordered by TSP weights. Gene expression was percentile rank normalized. EC-seq exome capture RNA-seq, TSP top scoring pairs of genes, WT-seq whole transcriptome RNA-seq.

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