Fig. 5: Shared functional genes identified by summary-database Mendelian randomization (SMR) analysis in Prostate Cancer (PCa) and Testicular Cancer (TC).
From: Comprehensive genomic insights into the genetic causality and comorbidity in urological cancers
A, B Manhattan plot of SMR results for PCa and TC in prostate tissue. Each point represents a gene, with the x-axis indicating the genomic position and the y-axis showing the −log₁₀ (P-value). C Venn diagram illustrating the overlap of SMR-identified risk genes between PCa and TC. D Differential gene expression analysis of 14 risk genes among tumor and normal tissues for PCa and TC from the TCGA database. 2 of these 16 risk genes lacked available data in the TCGA and were excluded from the analysis. The y-axis indicates normalized expression abundance (Z-score). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
