Fig. 6: Causal associations between ORMDL3, PARP14 and phenotypes across multiple categories in the FinnGen database. | npj Precision Oncology

Fig. 6: Causal associations between ORMDL3, PARP14 and phenotypes across multiple categories in the FinnGen database.

From: Transcriptome-wide Mendelian randomization and single-cell analysis during CD4+ T cell activation deciphers immunotherapeutic targets for colorectal cancer

Fig. 6

A Functional annotation of the top 20 significantly perturbed genes following the virtual KO of ORMDL3 and PARP14. B GSEA analysis of the top 10 of perturbed genes following virtual KO. C The bubble plot illustrates the causal associations between the targets and phenotypes from multiple categories in the FinnGen database (European individuals) (Top10), with a significance level set at FDR < 0.05. Colored points represent FDR < 0.05, while gray points indicate FDR > 0.05. The full list of associations is shown in Supplementary Table S26.

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