Table 3 Drug identification in the CMap database
Gene | Cancer | Pert_iname | Moa | FDR_nlog10 | Norm_cs | Affinity |
|---|---|---|---|---|---|---|
ORMDL3 | COAD | CNQX | Glutamate receptor antagonist | 15.353 | −1.868 | −7.5 kcal/mol |
ORMDL3 | COAD | seocalcitol | Vitamin D receptor agonist | 1.651 | −1.835 | −7.6 kcal/mol |
ORMDL3 | READ | clonazepam | GABA receptor agonist | 15.353 | −1.794 | −6.0 kcal/mol |
ORMDL3 | READ | APD-668 | Glucose dependent insulinotropic receptor agonist | 3.035 | −1.781 | −7.9 kcal/mol |
ORMDL3 | READ | prednisone | Glucocorticoid receptor agonist | 2.910 | −1.779 | −8.8 kcal/mol |
ORMDL3 | READ | fomocaine | Voltage-gated sodium channel blocker | 2.388 | −1.766 | −6.1 kcal/mol |
ORMDL3 | READ | SCH-28080 | ATPase inhibitor | 2.206 | −1.759 | −6.6 kcal/mol |
PARP14 | COAD | irbesartan | Angiotensin receptor antagonist | 15.353 | −1.801 | −9.3 kcal/mol |
PARP14 | COAD | tyrphostin-1 | EGFR inhibitor | 15.353 | −1.770 | −6.4 kcal/mol |
PARP14 | COAD | AV-608 | Tachykinin antagonist | 15.353 | −1.762 | −9.9 kcal/mol |
PARP14 | COAD | isoniazid | Cyclooxygenase inhibitor | 15.353 | −1.743 | −5.5 kcal/mol |
PARP14 | COAD | edaravone | Nootropic agent | 15.353 | −1.730 | −6.2 kcal/mol |
PARP14 | READ | oseltamivir-carboxylate | Neuraminidase inhibitor | 15.654 | −1.936 | −5.8 kcal/mol |
PARP14 | READ | haloperidol | Dopamine receptor antagonist | 15.654 | −1.757 | −8.1 kcal/mol |
PARP14 | READ | taurodeoxycholic-acid (TA) | Bile acid | 15.654 | −1.754 | −7.9 kcal/mol |
PARP14 | READ | carmustine | DNA inhibitor | 15.654 | −1.744 | −4.0 kcal/mol |
PARP14 | READ | APD-668 | Glucose dependent insulinotropic receptor agonist | 15.654 | −1.737 | −7.0 kcal/mol |
