Fig. 7: Single-cell sequencing reveals MARCO+ macrophages in various cancer types were characterized by diverse signaling pathways and were typically associated with tumor-promoting signatures. | npj Precision Oncology

Fig. 7: Single-cell sequencing reveals MARCO+ macrophages in various cancer types were characterized by diverse signaling pathways and were typically associated with tumor-promoting signatures.

From: Identification and characterization of MARCO-expressing tumor-associated macrophages in pancreatic ductal adenocarcinoma with pan-cancer relevance

Fig. 7: Single-cell sequencing reveals MARCO+ macrophages in various cancer types were characterized by diverse signaling pathways and were typically associated with tumor-promoting signatures.

A Proportion of TAMs from SKCM, STAD, COAD, NPC, GBM, LUAD, ESCA, PRAD, CHOL, KIRC, OS, GCTB, OV, THCA, BRCA, and LIHC at the single cell level in comparison to controls; B TAMs from SKCM, STAD, COAD, NPC, PDAC,GBM, LUAD, ESCA, PRAD, CHOL, KIRC, OS, GCTB, OV, THCA, BRCA, and LIHC expressed MARCO at the single cell level in comparison to controls; C UMAP plots of macrophage subpopulations in normal (left) and tumor (right) from SKCM, STAD, COAD, NPC, GBM, LUAD, ESCA, PRAD, CHOL, and KIRC; D Frequencies from scRNA-seq data of macrophage subpopulation in normal and tumor from SKCM, STAD, COAD, NPC, GBM, LUAD, ESCA, PRAD, CHOL, and KIRC; E GSEA analysis of MARCO+ macrophages and MARCO-macrophages from SKCM, STAD, COAD, NPC, GBM, LUAD, ESCA, PRAD, CHOL, and KIRC.

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