Table 4 Performance of radiologists alone and RENALNet-assisted radiologists for the multicenter validation cohorts

From: Noninvasive prediction of occult pT3a upstaging in localized ccRCC with radiogenomic insights and prognostic relevance

 

AUC (95% CI)

Sensitivity

Specificity

Accuracy

P

Validation Cohort Ⅰ

     

Radiologist alone

     

 Junior radiologist

0.619(0.561–0.675)

0.333

0.905

0.865

 

 Attending radiologist

0.676(0.620–0.729)

0.429

0.924

0.889

 

 Senior radiologist

0.760(0.707–0.808)

0.571

0.949

0.922

 

Radiologists with RENALNet

     

 Junior radiologist

0.761(0.708–0.808)

0.667

0.785

0.777

0.010*

 Attending radiologist

0.788(0.737–0.833)

0.619

0.898

0.878

0.017*

 Senior radiologist

0.855(0.810–0.893)

0.714

0.92

0.905

0.024*

Validation Cohort Ⅱ

     

Radiologist alone

     

 Junior radiologist

0.556(0.482–0.629)

0.349

0.764

0.668

 

 Attending radiologist

0.667(0.594–0.734)

0.465

0.868

0.775

 

 Senior radiologist

0.776(0.709–0.833)

0.628

0.924

0.856

 

Radiologists with RENALNet

     

 Junior radiologist

0.770(0.703–0.828)

0.814

0.618

0.663

<0.001*

 Attending radiologist

0.777(0.711–0.835)

0.674

0.806

0.775

0.001*

 Senior radiologist

0.848(0.788–0.896)

0.698

0.903

0.856

0.005*

Validation Cohort Ⅲ

     

Radiologist alone

     

 Junior Radiologist

0.660(0.596–0.721)

0.761

0.739

0.219

 

 Attending radiologist

0.684(0.621–0.743)

0.809

0.782

0.259

 

 Senior radiologist

0.733(0.671–0.789)

0.866

0.838

0.349

 

Radiologists with RENALNet

     

 Junior Radiologist

0.734(0.672–0.789)

0.799

0.778

0.263

0.028*

 Attending radiologist

0.767(0.711–0.820)

0.699

0.705

0.232

0.013*

 Senior radiologist

0.796(0.788–0.846)

0.847

0.825

0.333

0.040*

Validation Cohort Ⅳ

     

Radiologist alone

     

 Junior Radiologist

0.611(0.530–0.688)

0.304

0.917

0.827

 

 Attending radiologist

0.684(0.605–0.756)

0.391

0.977

0.891

 

 Senior radiologist

0.753(0.678–0.819)

0.522

0.985

0.917

 

Radiologists with RENALNet

     

 Junior Radiologist

0.716(0.638–0.785)

0.522

0.865

0.814

0.0497*

 Attending radiologist

0.748(0.673–0.814)

0.478

0.977

0.904

0.197

 Senior radiologist

0.809(0.739–0.868)

0.609

0.985

0.929

0.226

  1. P values represent results of DeLong’s test comparing the AUCs of radiologists alone versus radiologists assisted by RENALNet *Significant results.