Table 2 Prediction performance of HRD across three models using five-fold cross-validation on the training set

From: Predicting homologous recombination deficiency and treatment responses using a computed tomography-based foundation model: a preclinical study

Model

CT Type

AUC

Accuracy

Sensitivity

Specificity

HCR

40 kVp

0.79 [0.74, 0.85]

73% [68%, 78%]

69% [54%, 84%]

77% [60%, 94%]

80 kVp

0.77 [0.68, 0.87]

71% [63%, 80%]

68% [44%, 91%]

74% [51%, 97%]

Combined

0.79 [0.72, 0.85]

74% [68%, 80%]

76% [59%, 92%]

71% [54%, 87%]

sDL

40 kVp

0.78 [0.71, 0.85]

73% [69%, 77%]

72% [55%, 90%]

74% [60%, 88%]

80 kVp

0.71 [0.65, 0.77]

68% [64%, 72%]

71% [54%, 89%]

64% [45%, 84%]

Combined

0.74 [0.62, 0.86]

71% [62%, 79%]

76% [49%, 99%]

66% [36%, 95%]

FM

40 kVp

0.89 [0.84, 0.94]

84% [81%, 87%]

83% [73%, 93%]

86% [80%, 91%]

80 kVp

0.89 [0.85, 0.94]

84% [82%, 86%]

84% [77%, 92%]

85% [78%, 92%]

Combined

0.90 [0.84, 0.96]

85% [82%, 88%]

89% [81%, 97%]

81% [75%, 87%]

  1. HCR handcrafted radiomics, sDL supervised deep learning, FM foundation model, AUC area under the curve.