Fig. 6: Correlations between key radiomics features and the annual rate of changes in cognition in longitudinal analysis.

The red dots represent subjects in the CSVD-CI group and the blue triangles represent subjects in the CSVD-nonCI group. The annual rate of changes in the MoCA was significantly related to the values of logarithm_glszm_GrayLevelNonUniformity (A), logarithm_glszm_LargeAreaEmphasis(B), logarithm_glszm_SizeZoneNonUniformity (C), logarithm_glszm_SizeZoneNonUniformityNormalized(D), logarithm_glszm_SmallAreaEmphasis (E), logarithm_glszm_ZoneEntropy(F), logarithm_glszm_ZoneVariance (G) and logarithm_glszm_ZonePercentage(H) in the CSVD-CI group. CSVD-CI cerebral small vessel disease patients with cognitive impairment, CSVD-nonCI cerebral small vessel disease patients without cognitive impairment, MoCA Montreal Cognitive Assessment. Figure 6A–H were created using GraphPad Prism 8.