Table 1 Clinical characteristics of the populations used for training and testing
From: Emphysema progression risk in COPD using a localized foundational model of density evolution
Baseline Characteristics | COPDGene | ECLIPSE | ||||||
|---|---|---|---|---|---|---|---|---|
Phase 1–2 | Phase 2–3 | |||||||
All | Training | LEP Score Test | Local Model Test | HD Test | LD Test | |||
N | 4712 | 984 | 3728 | 795 | 1421 | 41 | 1058 | |
Race | Non-Hispanic White | 3341 (70.9%) | 727 (73.9%) | 2614 (70.1%) | 574 (72.2%) | 1013 (71.3%) | 23 (56.1%) | 1058 (100%) |
Non-Hispanic Black | 1371 (29.1%) | 257 (26.1%) | 1114 (29.9%) | 221 (27.8%) | 408 (28.7%) | 28 (43.9%) | 0 (0%) | |
Females | 2315 (49.1%) | 476 (48.4%) | 1839 (49.3%) | 381 (47.9%) | 722 (50.8%) | 24 (58.5%) | 416 (39.4%) | |
Age [y] | 59.8 (8.7) | 60.0 (8.5) | 59.7 (8.7) | 59.8 (8.3) | 59.2 (8.3) | 55.1 (7.6) | 61.5 (7.9) | |
BMI | 29.2 (6.1) | 28.9 (5.8) | 29.1 (6.2) | 29.1 (6) | 28.9 (6) | 29.1 (6.5) | 26.5 (5.2) | |
Height [cm] | 170.1 (9.6) | 170 (9.6) | 170.1 (9.5) | 170 (9.5) | 169.9 (9.4) | 169.1 (8.9) | 169.7 (9.0) | |
Pack-Years | 42.4 (23.5) | 43.2 (23.9) | 42.2 (23.4) | 43.0 (24.0) | 42.1 (22.8) | 40.1 (29.9) | 44.8 (28.4) | |
FEV1 [liter] | 2.4 (0.8) | 2.3 (0.8) | 2.4 (0.8) | 2.4 (0.8) | 2.4 (0.8) | 2.6 (0.9) | 1.71 (0.94) | |
FEV1/FVC | 0.7 (0.1) | 0.7 (0.1) | 0.7 (0.1) | 0.7 (0.1) | 0.7 (0.1) | 0.7 (0.1) | 0.51 (0.18) | |
No COPD | 2805 (60%) | 554 (57%) | 2251 (60%) | 489 (62%) | 860 (61%) | 29 (71%) | 218 (20.6%) | |
GOLD status | 1 | 427 (9%) | 87 (9%) | 340 (9%) | 65 (8%) | 162 (11%) | 5 (12%) | 0 |
2 | 907 (19%) | 199 (20%) | 708 (19%) | 152 (19%) | 256 (18%) | 5 (12%) | 353 (33.4%) | |
3 | 446 (10%) | 124 (12%) | 322 (9%) | 78 (10%) | 111 (8%) | 2 (5%) | 361 (34.1%) | |
4 | 102 (2%) | 20 (2%) | 82 (2%) | 11 (1%) | 19 (1%) | 0 (0%) | 126 (11.9%) | |
%LAA-950 | 5.2 (7.9) | 5.5 (8.1) | 5.1 (7.9) | 5.0 (7.3) | 5.2 (7.7) | 3.6 (6.2) | 10.7 (12.2) | |
Smoking Status | CS | 2439 (51.8%) | 507 (51.5%) | 1932 (51.8%) | 419 (52.7%) | 781 (55%) | 18 (43.9%) | 434 (41%) |
FS | 2273 (48.2%) | 477 (48.5%) | 1796 (48.2%) | 376 (47.3%) | 640 (45%) | 23 (56.1%) | 622 (59%) | |
