Table 3 Association between LEP Score, Δ%LAA-950, and various COPD Outcomes over a 5-year Period according to the risk groups defined by the quartiles Q1 = 0%–25%, Q2 = 25%–50%, Q3 = 50%–75%, and Q4 = 75%–100%
From: Emphysema progression risk in COPD using a localized foundational model of density evolution
Outcomes (n = 3728) | LEP Score, mean (std) | Δ%LAA-950, mean (std) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Q1 | Q2 | Q3 | Q4 | p-val | Q1 | Q2 | Q3 | Q4 | p-val. | |
FEV1/FVC @ P2 | 0.8 (0.1) | 0.7 (0.1) | 0.7 (0.1) | 0.5 (0.2) | <0.001 | 0.7 (0.1) | 0.7 (0.1) | 0.7 (0.1) | 0.6 (0.2) | <0.001 |
Change of FEV1 [ml/yr] | −30.3 (46.0) | −35.8 (48.6) | −40.9 (47.7) | −46.2 (48.7) | <0.001 | −41.5 (48.0) | −39.2 (49.1) | −33.5 (47.1) | −39.0 (48.0) | 0.004 |
Dlco @ P2 | 18.8 (5.2) | 19.7 (5.6) | 19.7 (6.2) | 15.0 (7.0) | <0.001 | 19.1 (6.3) | 19.1 (5.7) | 19.1 (6.0) | 15.9 (6.8) | <0.001 |
Change dist. walked [feet] | −102.7 (343.4) | −139.5 (360.2) | −141.2 (356.3) | −173.2 (370.7) | 0.001 | −138.9 (347.2) | −118.8 (360.6) | −139.1 (335.9) | −160.1 (387.8) | 0.111 |
Change MMRC | −0.1 (1.4) | 0.0 (1.2) | 0.1 (1.1) | 0.2 (1.2) | <0.001 | 0.0 (1.0) | −0.0 (1.3) | 0.0 (1.2) | 0.2 (1.3) | <0.001 |
