Fig. 9: Knockdown of COMP can inhibit the proliferation and metastasis of PCa. | npj Digital Medicine

Fig. 9: Knockdown of COMP can inhibit the proliferation and metastasis of PCa.

From: Integrative machine learning models predict prostate cancer diagnosis and biochemical recurrence risk: Advancing precision oncology

Fig. 9: Knockdown of COMP can inhibit the proliferation and metastasis of PCa.

A Verification of COMP knockdown efficiency in PCa cells. B, C Colony formation assay used to evaluate the effect of COMP on PCa cell proliferation. D, E Transwell assays to assess the effect of COMP on the metastatic ability of PCa cells. F Tumor modeling in male BALB/c nude mice. G, H Subcutaneous tumor volume change curve. I Final subcutaneous tumor weight. J Final subcutaneous tumor size. K, L IHC staining images of COMP and Ki-67 in subcutaneous tumors. M, N Measurement of lung metastasis luciferase activity via in vivo imaging system. **p < 0.01; ***p < 0.001.

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