Table 1 Overview of mathematical models

Model	Drug component	Neutrophil component	Blast component
M1	Pharmacokinetic	Baseline drug effect model²⁴	Baseline model for leukemic cells²⁵
M1a	Pharmacokinetic	Carrying capacity^c	Carrying capacity^c
M1b	Pharmacokinetic	Direct inhibition^b	Carrying capacity^c
M1b_w	Pharmacokinetic	Direct inhibition^b	Interpolated data^d
M1c	Pharmacokinetic	Direct inhibition	Logistic growth
M2a	Simplified^a	Baseline drug effect model	Baseline model for leukemic cells
M2b	Simplified^a	Direct inhibition^b	Carrying capacity
M2c	Simplified^a	Direct inhibition^b	Logistic growth
M2d	Simplified, venetoclax only, same effects on blasts and healthy cells	Direct inhibition^b	Logistic growth
M2b_w	Simplified^a	Direct inhibition^b	Interpolated data^d

^aThe drug effect is proportional to its dosage (or 0 when not in treatment).
^bBlast cells inhibits neutrophil lineage.
^cCancer and normal cells compete for space as there is a maximum number of cells in the bone marrow.
^dPopulation of blast cells are interpolated and used as inputs in the model of neutrophil lineage.

Quick links

Search