Fig. 4: Individual-level stratification using the distribution of median values of IC.
From: Information content as a health system screening tool for rare diseases
Fine-grained view over the distribution of the p-values obtained from performing a statistical significance test of the distribution of the median IC of a longitudinal profile against the control group at different numbers of encounters for Genetic disease patients. The top panel displays the distribution of p-values for each stratified group (ranging from 2 to 6 encounters), indicating the statistical significance of differences observed in the dataset. The middle panel provides histograms showing the normalized frequency of medical concepts across different stratification groups, with red bars representing the control population, blue bars the significant cases and green bars the non-significant cases. The bottom panel presents the distribution of IC values for each stratification group, comparing significant, non-significant, and normal cases.
