Fig. 3: Spatial localization features of distinct cell populations in the GC microenvironment. | npj Digital Medicine

Fig. 3: Spatial localization features of distinct cell populations in the GC microenvironment.

From: Multi-dimensional omics integrated machine learning framework identifies macrophage-fibroblast-tumor co-infiltration patterns to predict prognosis in gastric cancer

Fig. 3: Spatial localization features of distinct cell populations in the GC microenvironment.

A Heatmaps showing the colocalization of cells from cell2location-derived deconvolution results (calculated via the Mistyr algorithm) across 8 GC spatial transcriptomic sections. The upper panel represents intra-spot colocalization, and the lower panel represents inter-neighborhood spot colocalization. B–D Visualization of regions of interest (ROI) for the spatial localization of macrophages, fibroblasts, and tumor cells. Distinct colors correspond to different cell types, and the intensity of each color reflects the relative abundance of the respective cell type. E, F Multiplex immunofluorescence images depicting the spatial localization of macrophages, fibroblasts, and tumor cells.

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