Fig. 8: Effects of engineered exosomes loaded with PKM2-vMO on the malignant phenotype of CML drug-resistant cells. | npj Digital Medicine

Fig. 8: Effects of engineered exosomes loaded with PKM2-vMO on the malignant phenotype of CML drug-resistant cells.

From: Machine learning-driven glycolytic subtyping and exosome-based PKM splicing modulation overcome drug resistance in hyper-glycolytic myeloid leukemia

Fig. 8

A, B RT-qPCR and Western blot detection of changes in PKM1 and PKM2 mRNA and protein expression in K562/G01 cells cocultured with engineered exosomes loaded with vMO. Effects of engineered exosomes loaded with PKM2-vMO on imatinib resistance (C, D) and apoptosis (E, F) in K562/G01 cells and the viability of HS-5 cells (G).

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