Table 1 Baseline clinical characteristics of study population

From: Artificial intelligence-driven multivariate integration for pulmonary arterial pressure prediction in pulmonary hypertension

Variable

Total (n = 120)

Group non-PH (n = 43)

Group PH (n = 77)

p value

Female, sex (%)

76 (63.3)

24 (55.8)

52 (67.5)

0.201

Age (years)

31.0 (23.0, 43.8)

23.0 (22.0, 26.0)

38.0 (29.5, 47.5)

<0.001

BMI (kg/m2)

22.85 (20.29, 25.33)

23.04 (20.39, 26.76)

22.77 (20.18, 24.86)

0.268

PH subjects, n (%)

    

 Group 1

–

–

64 (83.1)

 

 Group 2

–

–

0 (0)

 

 Group 3

–

–

1 (1.3)

 

 Group 4

–

–

11 (14.3)

 

 Group 5

–

–

1 (1.3)

 

Transthoracic echocardiography

    

 LV (cm)

4.35 (4.00, 4.70)

4.40 (4.20, 4.70)

4.30 (3.70, 4.70)

0.179

 LA (cm)

3.29 ± 0.60

3.06 ± 0.43

3.41 ± 0.65

0.001

 RV (cm)

4.02 ± 1.03

3.18 ± 0.42

4.49 ± 0.97

<0.001

 RA (cm)

4.14 ± 0.98

3.32 ± 0.45

4.59 ± 0.90

<0.001

 PA (cm)

2.70 (2.20, 3.48)

2.10 (2.00, 2.40)

3.30 (2.65, 3.60)

<0.001

 TRV (m/s)

3.3 (0.0, 4.3)

0.0 (0.0, 1.9)

4.0 (3.3, 4.8)

<0.001

 LVEF (%)

65.0 (60.0, 68.0)

65.0 (61.0, 67.0)

65.0 (60.0, 69.0)

0.637

 6MWD (m)

479.11 ± 89.05

522.55 ± 56.29

454.86 ± 94.88

<0.001

WHO functional class, n (%)

   

0.001

 I–II

102 (85.0)

43 (100)

59 (76.6)

 

 III–IV

18 (15.0)

0

18 (23.4)

 

 HB (g/L)

131.0 (119.3, 145.5)

131.0 (120.0, 145.0)

129.0 (116.0, 145.9)

0.943

 NT-proBNP (pg/mL)

118.0 (45.3, 513.8)

38.1 (17.0, 74.0)

337.0 (98.4, 912.0)

<0.001

 UA (μmol/L)

325.9 (264.0, 408.9)

291.0 (247.0, 368.0)

342.0 (295.2, 438.2)

0.014

 ALT (U/L)

16.5 (12.0, 25.0)

13.0 (10.0, 26.0)

18.0 (14.0, 24.5)

0.014

 AST (U/L)

20.0 (17.0, 26.8)

18.0 (15.0, 22.0)

22.0 (18.0, 28.5)

0.002

 ALB (g/L)

41.82 ± 4.47

42.81 ± 3.71

41.27 ± 4.77

0.069

 CREA (μmol/L)

66.7 (56.3, 78.7)

63.0 (53.3, 73.4)

68.5 (57.5, 80.9)

0.071

RHC

    

 mPAP (mmHg)

31.0 (17.0, 50.8)

16.0 (14.0, 18.0)

43.0 (31.5, 55.5)

<0.001

 PVR (Wu)

3.00 (1.51, 7.23)

1.24 (1.08, 1.67)

6.00 (3.21, 10.08)

<0.001

 TPR (Wu)

4.26 (2.67, 9.45)

2.48 (2.23, 3.00)

7.30 (4.37, 11.89)

<0.001

 CO (L/min)

6.45 (5.20, 7.56)

6.53 (5.60, 7.07)

6.40 (4.81, 7.91)

0.582

 CI (L/min ⋅ m2)

3.52 (2.99, 4.39)

3.49 (3.17, 3.99)

3.55 (2.85, 4.80)

0.571

 RAP (mmHg)

4.0 (3.0, 8.0)

3.0 (2.0, 3.0)

6.0 (4.0, 10.0)

<0.001

 PAWP (mmHg)

8.0 (7.0, 10.0)

8.0 (7.0, 9.0)

9.0 (7.0, 12.0)

0.010

  1. The data are expressed as the mean ± standard deviation, quantity (percentage), or median (interquartile range). 6MWD 6-min walking distance, ALB Albumin, ALT Alanine Aminotransferase, AST Aspartate Aminotransferase, BMI body mass index, CHD congenital heart disease, CI cardiac index, CO cardiac output, CREA Creatinine, HB Hemoglobin, mPAP mean pulmonary arterial pressure, LA left atrium, LV left ventricle, LVEF left ventricular ejection fraction, NT-pro BNP N-terminal pro-B-type natriuretic peptide, PA pulmonary artery, PAWP pulmonary arterial wedge pressure, PH pulmonary hypertension, PVR pulmonary vascular resistance, RA right atrium, RAP right atrial pressure, RV right ventricle, TPR total pulmonary vascular resistance, TRV tricuspid regurgitation velocity, UA Uric acid.
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