Fig. 2: IFI27 temporal dynamics following experimental viral challenge. | npj Digital Medicine

Fig. 2: IFI27 temporal dynamics following experimental viral challenge.

From: Explainable AI multiomics analysis reveals shared and divergent host responses in COVID-19 and influenza

Fig. 2: IFI27 temporal dynamics following experimental viral challenge.

Z-score-normalized peripheral blood IFI27 expression over 0–96 hours post-inoculation across influenza, RSV, and COVID-19 cohorts (dashed line indicates baseline, z = 0). Influenza shows an early peak (~24 h) followed by a rapid decline; RSV rises more slowly and peaks later with a more sustained elevation (~2 h); COVID-19 exhibits an intermediate, broader response. These kinetics support a shared interferon backbone with virus-specific temporal signatures.

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