Table 5 Characteristics of GEO Datasets Included in the Study
Dataset | Region | Platform | Total N (AD / NC) | Mean Age (AD / NC) | Male ratio (AD / NC) | Sample Type | Brain Region | Diagnosis Criteria | Function |
|---|---|---|---|---|---|---|---|---|---|
GSE5281 | USA | GPL570 | 161 (87/74) | 79.79/79.51 | 57.47%/71.62% | brain | Entorhinal Cortex /Hippocampus /Medial Temporal Gyrus /Posterior Cingulate /Superior Frontal Gyrus /Posterior Cingulate /Primary Visual Cortex | Clinical diagnosis+Braak stage+MMSE | Training Cohort |
GSE84422 | USA | GPL96/ GPL97/ GPL570 | 62 (34/28) | 88.15/82.07 | 0%/57.14% | brain | Amygdala/Nucleus Accumbens | Clinical diagnosis + Braak stage + CERAD | Training Cohort |
GSE122063 | USA | GPL16699 | 100 (56/44) | 78.6/80.9 | 33%/50% | brain | Frontal cortex/Temporal cortex | Clinical diagnosis + autopsy | Testing Cohort |
GSE132903 | Arizona | GPL10558 | 195 (97/98) | 85.02/84.98 | 51.5%/51.0% | brain | Middle temporal gyrus | Clinical diagnosis + Braak stage + MMSE | Testing Cohort |
GSE28146 | USA | GPL570 | 30 (22/8) | 86.38/86.27 | 27.27%/75% | brain | Hippocampal specimens | Clinical diagnosis + Braak stage + MMSE | Testing Cohort |
GSE48350 | USA | GPL570 | 253 (80/173) | 89.22/80.71 | 41.25%/52.60% | brain | Postcentral gyrus/Superior frontal Gyrus/Hippocampus/Entorhinal cortex | Clinical diagnosis + Braak stage + MMSE | Testing Cohort |
GSE36980 | Japan | GPL6244 | 80 (33/47) | 93.06/78.30 | 43.75%/43.48% | brain | Frontal cortex/Temporal cortex/Hippocampus | Clinical diagnosis + Braak stage | Testing Cohort |
GSE37263 | Singapore | GPL5175 | 16 (8/8) | 72.63/80.15 | 62.5%/62.5% | brain | Neocortex | Clinical diagnosis + autopsy | Testing Cohort |
GSE29378 | USA | GPL6947 | 63 (31/32) | 77.3/81.7 | 52.94%/68.75% | brain | Hippocampus | Clinical diagnosis + Braak stage | Testing Cohort |
