Fig. 7: DTNA⁺ macrophage-derived PLG accelerates liver fibrosis via the complement and coagulation cascades. | npj Digital Medicine

Fig. 7: DTNA⁺ macrophage-derived PLG accelerates liver fibrosis via the complement and coagulation cascades.

From: Integrating multi-omics and machine learning systematically deciphers cellular heterogeneity and fibrotic regulatory networks in the progression from MASLD to MASH

Fig. 7: DTNA⁺ macrophage-derived PLG accelerates liver fibrosis via the complement and coagulation cascades.

A Volcano plot of differentially expressed genes in DTNA⁺ macrophages between high-PLG and low-PLG groups. B, C GSEA revealing significant enrichment of the “Complement and coagulation cascades” pathway in the high-PLG group. D, E Spatial transcriptomics showing pronounced co-localization of DTNA⁺ macrophages and aHSCs in MASH sections; correlation scatter plot confirms a significant positive association (p < 0.001).

Back to article page