Extended Data Fig. 5: Spatiotemporal pattern of electrographic seizure dynamics from the 3-level seizure states under closed-loop tFUS epilepsy control with Isppa dose-regulation.
From: A shape-morphing cortex-adhesive sensor for closed-loop transcranial ultrasound neurostimulation
The selected durations of interest were from the representative neurosignal trace in Dose #1 (peaks *1 to *3 in seizure phase II), Dose #2 (peaks *4 to *7 in seizure phase III), and Dose #3 (peak 8 in seizure phase IV) epoch respectively. The sequential topographic frames from the seizure-phase series illustrates the representative drift of two-dimensional ictal activity being suppressed by the closed-loop Isppa-regulating tFUS electroceuticals.
