Extended Data Fig. 5: Long-term recording stability of ki-MEAs in rat brains.
From: Flexible kirigami microelectrode arrays for neuronal activity recordings in non-human primate brains
a, Schematic illustration of an implanted 120-channel ki-MEA covering M2 and Cg1 regions of the left and right hemispheres in a rat brain. M2: secondary motor area; Cg 1: cingulate area 1. The three brain slices were at 1.0 mm, 2.2 mm, and 3.4 mm anterior to bregma. The brain atlas images were adapted from the Waxholm Space atlas of the Sprague Dawley rat brain (RRID:SCR_017124, atlas version: 1.0.0)49,50. b, Neuron yield of ki-MEAs from 2 to 8 weeks post implantation in rats (n = 5 rats, Mean ± SD). n.s.: not significant by one-way ANOVA (two-sided test). Results showed no statistically significant difference between groups (F(3,16) = 2.30, P = 0.116). c, d, Spike amplitude and firing rates of recorded neurons from 2 to 8 weeks post implantation in rats (n = 5). Box plots in c and d: grey points indicated data points, red lines indicated median, bottom and top box edges indicated percentiles of 25% (Q1) and 75% (Q3), and whisker edges indicated min/max values, respectively.
