Ingestible electronic devices could transform gastrointestinal medicine by combining diagnostic and therapeutic functions into a single miniature device. But challenges related to device miniaturization, power-efficient integrated circuit design and data security remain to be addressed.
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Acknowledgements
We are grateful for the review and suggestions from S.-Y. Yang and Z. Kang, and J. Chen for providing a photo of the FIREFLI device. G.T., R.L. and A.C. report receiving funding from the Advanced Research Projects Agency for Health (ARPA-H) under award no. D24AC00040-00. The content is solely the responsibility of the authors and does not necessarily represent the official views of the Advanced Research Projects Agency for Health.
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P.S. is a federal employee of the Advanced Research Projects Agency for Health. A.B. is an employee of Texas Instruments, Inc. G.T., R.L. and A.C. report being co-inventors on multiple patents and patent applications encompassing aspects of ingestible electronic devices. Complete details of all relationships for profit and not-for-profit for G.T. and R.L. can be found in the Supplementary Information.
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Traverso, G., Sheehan, P., Bahai, A. et al. The potential of miniaturized ingestible electronics. Nat Electron 9, 5–7 (2026). https://doi.org/10.1038/s41928-025-01561-5
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DOI: https://doi.org/10.1038/s41928-025-01561-5