Fig. 7: ACT mutants of parkin are mildly impaired in autoubiquitination.
From: Naturally occurring hyperactive variants of human parkin
a Time-course of the autoubiquitination activity of phosphorylated parkin with pUb bound. b Sequence alignment of parkin ACT elements from different species. c Quantification of the decrease of unmodified phosphorylated parkin over time from two replicate experiments (n = 2). The activity levels of the controls (WT, pWT, and pK161N) are shown only on the first graph for clarity.
