Table 1 Demographics, baseline profiles and IVF-ET laboratory indicators of women with or without PCOS and with or without MetS

From: CTBP1 links metabolic syndrome to polycystic ovary syndrome through interruption of aromatase and SREBP1

Characteristics

(A) Control without MetS (N = 34)

(B) Control with MetS (N = 15)

(C) PCOS without MetS (N = 29)

(D) PCOS with MetS (N = 18)

P Value A vs. B

P - Value A vs. C

P - Value A vs. D

P - Value C vs. D

Age (years) #

29.882 ± 5.098

31.333 ± 6.309

28.690 ± 3.048

30.778 ± 4.545

0.557

0.334

0.487

0.111

BMI (kg/m) !

21.638 ± 2.329

25.553 ± 3.215

24.038 ± 2.547

26.528 ± 2.764

0.000

0.000

0.000

0.003

Basal E2 (pg/mL) #

39.887 ± 17.218

43.693 ± 21.667

43.144 ± 15.838

46.16 ± 18.504

0.931

0.424

0.233

0.615

Basal T (ng/mL) #

0.285 ± 0.131

0.299 ± 0.116

0.436 ± 0.185

0.546 ± 0.253

0.803

0.002

0.000

0.148

Basal FSH (mIU/mL) #

6.936 ± 1.368

6.7 ± 3.446

6.174 ± 1.371

5.636 ± 1.322

0.461

0.013

0.009

0.325

Basal LH (mIU/mL) #

6.482 ± 4.481

5.931 ± 3.055

8.006 ± 4.393

8.588 ± 4.66

0.811

0.124

0.122

0.861

Basal LH/FSH #

0.943 ± 0.585

1.27 ± 1.319

1.306 ± 0.659

1.645 ± 1.105

0.649

0.004

0.022

0.444

Basal P (ng/mL) #

0.464 ± 0.388

0.539 ± 0.742

0.38 ± 0.297

0.978 ± 2.459

0.385

0.225

0.780

0.577

AMH #

3.655 ± 1.95

3.145 ± 1.847

5.764 ± 2.366

6.444 ± 4.738

0.508

0.000

0.017

0.939

TG (mmol/L) #

0.91 ± 0.413

2.732 ± 1.622

1.324 ± 0.884

2.147 ± 1.113

0.000

0.012

0.000

0.003

TC (mmol/L) !

4.355 ± 0.627

4.255 ± 0.692

4.382 ± 0.639

4.8 ± 0.963

0.620

0.869

0.089

0.114

HDL (mmol/L) #

1.579 ± 0.354

1.103 ± 0.264

1.474 ± 0.284

1.176 ± 0.139

0.000

0.249

0.000

0.000

LDL (mmol/L) !

2.516 ± 0.562

2.437 ± 0.702

2.631 ± 0.66

3.082 ± 0.951

0.703

0.458

0.029

0.089

FBG (mmol/L) #

4.856 ± 0.472

5.431 ± 0.79

4.721 ± 0.448

5.087 ± 1.043

0.016

0.279

0.893

0.255

SBP (mmHg) !

111.324 ± 9.524

123.357 ± 11.493

114.069 ± 10.627

116.722 ± 14.712

0.001

0.284

0.115

0.477

DBP (mmHg) !

72.206 ± 7.927

82.067 ± 10.853

74.276 ± 7.801

74.722 ± 8.043

0.001

0.302

0.284

0.851

Total Gn days #

12.765 ± 2.23

15.467 ± 3.021

13.448 ± 2.983

14.278 ± 2.024

0.004

0.097

0.011

0.318

Total Gn dose (IU) #

2141.471 ± 786.816

3441.133 ± 1302.544

2063.569 ± 708.568

2433.917 ± 672.904

0.001

0.615

0.166

0.058

Serum E2 on HCG day

4354.242 ± 2458.641

2345.353 ± 1006.858

3993.852 ± 1850.437

3523.167 ± 1948.435

0.000

0.532

0.193

0.418

Serum LH on HCG day

1.369 ± 1.524

2.417 ± 7.35

0.787 ± 0.646

0.536 ± 0.538

0.593

0.053

0.007

0.179

Serum P on HCG day

1.188 ± 0.607

0.836 ± 0.679

0.938 ± 0.462

0.889 ± 0.492

0.085

0.075

0.079

0.734

No. of ≥14 mm follicles on hCG day #

10.455 ± 2.063

8.133 ± 3.182

11.414 ± 2.934

11.167 ± 3.034

0.004

0.248

0.611

0.716

No. of follicles aspirated !

15.176 ± 5.248

13.8 ± 7.428

15.172 ± 5.312

17.5 ± 6.546

0.462

0.998

0.170

0.189

No. of mature oocytes !

12.471 ± 4.986

10.467 ± 5.397

11.414 ± 5.408

14.333 ± 5.552

0.212

0.423

0.224

0.082

Mature oocytes rate #

0.809 ± 0.136

0.78 ± 0.265

0.745 ± 0.234

0.833 ± 0.145

0.579

0.428

0.419

0.273

Rate of fertilization !

0.698 ± 0.155

0.626 ± 0.209

0.673 ± 0.224

0.665 ± 0.162

0.181

0.594

0.465

0.895

Cleavage rate #

0.994 ± 0.023

0.929 ± 0.258

0.985 ± 0.041

0.989 ± 0.033

0.404

0.302

0.526

0.777

High qualified embryo rate #

0.693 ± 0.274

0.725 ± 0.208

0.693 ± 0.26

0.572 ± 0.312

0.811

0.895

0.140

0.185

Blastocyst formation rate #

0.643 ± 0.238

0.537 ± 0.242

0.543 ± 0.261

0.477 ± 0.294

0.177

0.144

0.043

0.327

  1. #Indicates that the data do not conform to the normal distribution, statistic method: Mann-Whitney U. !Indicates that the data conform to a normal distribution, statistic method: Independent sample t-test. Data were presented as means ± SD, proportion in % (95% CI). AMH anti-Mullerian hormone, BMI Body mass index, DBP Diastolic blood pressure, E2 estradiol, FBG fasting blood-glucose, FSH Follicle-stimulating hormone, FT3 Free Triiodothyronine, FT4 free thyroxine, Gn gonadotropin, HDL high-density lipoprotein, LDL Low-density lipoprotein, LH Luteinizing hormone, MetS Metabolic syndrome, P Progesterone, PCOS Polycystic ovary syndrome, PRL Prolactin, SBP Systolic blood pressure, T Testosterone; TC serum total cholesterol, TG Triglycerides, TSH Thyroid-stimulating hormone.
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