Fig. 6: Oxaliplatin-induced CRT translocation from the cytosol to the plasma membrane is inhibited by selinexor. | Communications Biology

Fig. 6: Oxaliplatin-induced CRT translocation from the cytosol to the plasma membrane is inhibited by selinexor.

From: HMGB2-induced calreticulin translocation required for immunogenic cell death and ferroptosis of cancer cells are controlled by the nuclear exporter XPO1

Fig. 6: Oxaliplatin-induced CRT translocation from the cytosol to the plasma membrane is inhibited by selinexor.The alternative text for this image may have been generated using AI.

Analysis of CRT in the cytosol and on the plasma membrane after incubations with PBS buffer (control), 100 μM oxaliplatin, or 100 μM oxaliplatin + 75 nM selinexor for 24 h. a Cytosol of A549 cells. b Plasma membrane of A549 cells. c Cytosol of HCT116 cells. d Plasma membrane of HCT116 cells. Western blots are shown in the upper panels and ImageJ88 quantification of blots in the lower panels. FASN and E-cadherin were used as loading controls for cytosolic proteins and membrane proteins, respectively. Western blot data are from three biological replicates, all error bars are expressed as ±SD.

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