Fig. 3: Decreased transcriptomic age of classical monocytes, naive B and T cells in moderate COVID-19 compared to healthy individuals.

Predicted age of a classical monocyte cells, b naive thymus-derived CD4-positive alpha-beta T cells, c naive thymus-derived CD8-positive alpha-beta T cells, and d naive B cells from healthy and COVID-19-afflicted donors in the Yoshida et al., Liu et al., and Stephenson et al. datasets, respectively, applying the correspondent cell-type-specific single-cell aging clocks. We compared the different severity stages to the healthy group. The p-value between the healthy and moderate groups was calculated by a generalized linear model fitted to the predicted age with severity as the independent variable and age as a confounder variable. The sample size (n) of each group is also shown for each panel.