Fig. 4: Genes supporting the rejuvenation of classical monocytes and naive B cells in moderate COVID-19.

Normalized expression of genes in classical monocyte cells from the a Yoshida et al., b Liu et al., and the c Stephenson et al. dataset supporting the decreased predicted age of classical monocytes in the moderate stage of COVID-19 compared to healthy individuals. d The regression coefficient of the supporting genes in the five classical monocyte cross-validation clocks. The bars illustrate the distribution of the coefficients. Normalized expression of genes in naive B cells from the e Yoshida et al. f Liu et al., and g Stephenson et al. dataset supporting the decreased predicted age of naive B cells of donors in the moderate stage of COVID-19 compared to healthy individuals. h The regression coefficient of the supporting genes in the naive B cell cross-validation clocks. The bars illustrate the distribution of the coefficients. The p-value between the two groups was calculated by a generalized linear model fitted to the gene expression with severity as the independent variable and age as a confounder variable. The sample size (n) of each group is also shown for the relevant panels.