Fig. 5: Transcriptomic rejuvenation of human embryo cells at the morulae and blastocyst stages.

a Predicted ages of cells from different embryonic development stages in the Yan et al. dataset, given by the 9 best-performing cell-type-specific clocks based on the AIDA dataset. b Predicted ages of cells from different embryonic development stages in the Petropoulos et al. dataset. c The average predicted age of cells in the Yan et al. dataset, derived from the predictions of all the cell-type-specific clocks (except for the dendritic cell and erythrocyte clocks). Embryonic days 3, 4, and 5–7 correspond to the 8-cell, morulae, and the (pre-implantation) blastocyst stage, respectively. d The average predicted age of cells in the Petropoulos et al. dataset.