Fig. 5: HOXB3 elevated PARK7 expression by activating PARK7 transcription. | Communications Biology

Fig. 5: HOXB3 elevated PARK7 expression by activating PARK7 transcription.

From: STUB1 suppresses paclitaxel resistance in ovarian cancer through mediating HOXB3 ubiquitination to inhibit PARK7 expression

Fig. 5

a, c PARK7 expression was measured in samples from OC patients using RT-qPCR and western blot. b PARK7 expression was examined in tumor samples from chemotherapy resistant and chemotherapy sensitive OC patients using RT-qPCR. d The binding site between HOXB3 and PARK7 promoter was predicted using JASPAR database. e The interaction between HOXB3 and PARK7 promoter was validated by luciferase activity assay. f, g HOXB3 and PARK7 expression were measured in oe-HOXB3-transfected PTX-resistant OC cells by RT-qPCR and western blot. N = 3. *P < 0.05; **P < 0.01, ***P < 0.001.

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